Sum across rows and columns:

import pandas as pd

df = pd.DataFrame([[10, 20, 30, 40], [7, 14, 21, 28], [5, 5, 0, 0]],
                  columns=['Apple', 'Orange', 'Banana', 'Pear'],
                  index=['Basket1', 'Basket2', 'Basket3'])

df['Sum Basket'] = df.sum(axis=1)
df.loc['Sum Fruit'] = df.sum()

print(df)

C:\pandas>python example40.py
           Apple  Orange  Banana  Pear  Sum Basket
Basket1       10      20      30    40         100
Basket2        7      14      21    28          70
Basket3        5       5       0     0          10
Sum Fruit     22      39      51    68         180
 
C:\pandas>